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Literature summary for 3.4.21.5 extracted from

  • Bukys, M.A.; Kim, P.Y.; Nesheim, M.E.; Kalafatis, M.
    A control switch for prothrombinase: characterization of a hirudin-like pentapeptide from the COOH terminus of factor Va heavy chain that regulates the rate and pathway for prothrombin activation (2006), J. Biol. Chem., 281, 39194-39204.
    View publication on PubMed
Search for more literature for 3.4.21.5

Protein Variants

Protein Variants Comment Organism
R155A/R284A/R271A site-directed mutagenesis, the mutant enzyme can be cleaved only at Arg320, cleavage is completely inhibited by Asp-Tyr-Asp-Tyr-Gln Homo sapiens
R155A/R284A/R320A site-directed mutagenesis, the mutant enzyme can be cleaved only at Arg271, no inhibition of cleavage by Asp-Tyr-Asp-Tyr-Gln Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Asp-Tyr-Asp-Tyr-Gln a pentapeptide encompassing amino acid sequence 695–699 from the C-terminus of the heavy chain of factor Va inhibits prothrombin activation by prothrombinase in a competitive manner with respect to substrate, mechanism, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens a hirudin-like pentapeptide from the COOH terminus of factor Va heavy chain regulates the rate and pathway for prothrombin activation, prothrombinase complex regultion, overview ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification the zymogen can be activated via different pathways, the pre2 pathway: cleavage at Arg271 and prethrombin 2 of prothrombin by the membrane-bound factor Xa alone, the meizo pathway: factor Va directs prothrombin activation by factor Xa through the meizothrombin pathway, characterized by initial cleavage at Arg320, the prothrombinase complex is responsible for activation, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information a hirudin-like pentapeptide from the COOH terminus of factor Va heavy chain regulates the rate and pathway for prothrombin activation, prothrombinase complex regultion, overview Homo sapiens ?
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 ?