Any feedback?
Literature summary for 3.4.21.5 extracted from
- Galectin-8 and galectin-9 are novel substrates for thrombin (2006), Glycobiology, 16, 15C-20C.
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Homo sapiens |  |
| Na+ | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| galectin-8 + H2O | Homo sapiens | although intact isoform G8L stimulates neutrophil adhesion to substrate more efficiently than isoform G8M, the activity of isoform G8L but not that of isoform G8M decreases on thrombin digestion, overview | ? | - |
? | |
| galectin-9 + H2O | Homo sapiens | thrombin treatment almost completely abolishes eosinophil chemoattractant activity of isoform G9L, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| galectin-8 + H2O | although intact isoform G8L stimulates neutrophil adhesion to substrate more efficiently than isoform G8M, the activity of isoform G8L but not that of isoform G8M decreases on thrombin digestion, overview | Homo sapiens | ? | - |
? | |
| galectin-8 + H2O | cleavage site is -IAPRT- residing within the linker peptide, isoforms with the longest linker peptide, galectin-8L and galectin-9L, are highly susceptible to thrombin cleavage, whereas the predominant isoforms, galectin-8M and galectin-9M, and other members of human galectin family so far examined are resistant to thrombin, overview, human and murine substrates, and recombinant GST-tagged wild-type and mutant substrate, sbstrate specificity, overview | Homo sapiens | ? | - |
? | |
| galectin-9 + H2O | thrombin treatment almost completely abolishes eosinophil chemoattractant activity of isoform G9L, overview | Homo sapiens | ? | - |
? | |
| galectin-9 + H2O | cleavage site is -PRPRG- residing within the linker peptide, isoforms with the longest linker peptide, galectin-8L and galectin-9L, are highly susceptible to thrombin cleavage, whereas the predominant isoforms, galectin-8M and galectin-9M, and other members of human galectin family so far examined are resistant to thrombin, overview, human and murine substrates, and recombinant GST-tagged wild-type and mutant substrate, sbstrate specificity, overview | Homo sapiens | ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
