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Literature summary for 3.4.21.5 extracted from

  • Gianni, S.; Ivarsson, Y.; Bah, A.; Bush-Pelc, L.A.; Di Cera, E.
    Mechanism of Na+ binding to thrombin resolved by ultra-rapid kinetics (2007), Biophys. Chem., 131, 111-114.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.5

Protein Variants

Protein Variants Comment Organism
S195A catalytically inactive mutant enzyme Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information ultra-rapid kinetics of Na+-binding to wild-type and mutant S195A thrombin Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Na+ two-step mechanism of Na+ binding to thrombin resolved by ultra-rapid kinetics Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens Na+ binding to thrombin is an interaction at the basis of the procoagulant and prothrombotic roles of the enzyme in the blood ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Na+ binding to thrombin is an interaction at the basis of the procoagulant and prothrombotic roles of the enzyme in the blood Homo sapiens ?
-
 ?
additional information Ser195 is the catalytic residue Homo sapiens ?
-
 ?