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Literature summary for 3.4.21.5 extracted from

  • Weitz, J.I.
    A novel approach to thrombin inhibition (2003), Thromb. Res., 109 Suppl 1, S17-22.
    View publication on PubMed
Search for more literature for 3.4.21.5

Application

Application Comment Organism
medicine enzyme inhibitors are used in therapy and prevention of venous and arterial thrombosis, inhibition mode, efficiency and safety, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
antithrombin inactive if complexed with heparin Homo sapiens
argatroban small site-directed direct thrombin inhibitor Homo sapiens
bivalirudin synthetic hirudin derivative Homo sapiens
efegatran small site-directed direct thrombin inhibitor Homo sapiens
heparin inactive if complexed with antithrombin Homo sapiens
Hirudin irreversible, direct thrombin inhibitor, competitive to fibrin, noncompetitive to fibrin Homo sapiens
melagatran reversible, active site directed direct thrombin inhibitor, active form of ximelagatran Homo sapiens
additional information schematic representation of inhibition mode Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular bound to fibrin or soluble Homo sapiens
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-

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
plasma extracellular, bound to fibrin or soluble Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
thrombin-activable finrinolysis inhibitor + H2O i.e. TAFI Homo sapiens ?
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 ?