Literature summary for 3.4.21.5 extracted from

Skordalakes, E.; Dodson, G.G.; Green, D.S.; Goodwin, C.A.; Scully, M.F.; Hudson, H.R.; Kakkar, V.V.; Deadman, J.J.
Inhibition of human alpha-thrombin by a phosphonate tripeptide proceeds via a metastable pentacoordinated phosphorus intermediate (2001), J. Mol. Biol., 311, 549-555.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
crystal growth of enzyme complexed with acyl (alpha-aminoalkyl)phosphonate inhibitor within 1 week, formation of 2 different complexes, pentacoordinated complex I and tetracoordinated complex II, X-ray diffraction structure determination and analysis at 1.4-1.75 A	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
benzyloxycarbonyl-D-Dpa-Pro-Mpg(OPh)2	tripeptide acyl (alpha-aminoalkyl)phosphonate inhibitor, acts via formation of a metastable pentacoordinated phosphorus intermediate that is non-covalently bound to Ser195, inhibition mechanism	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
selective cleavage of Arg-/-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B	serine protease, mechanism and substrate binding	Homo sapiens	a

Synonyms

Synonyms	Comment	Organism
alpha-thrombin	-	Homo sapiens

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Release 2023.1 (January 2023)