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Literature summary for 3.4.21.5 extracted from

  • Myles, T.; Yun, T.H.; Leung, L.L.
    Structural requirements for the activation of human factor VIII by thrombin (2002), Blood, 100, 2820-2826.
    View publication on PubMed
Search for more literature for 3.4.21.5

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information construction of diverse mutants by site-directed mutagenesis, reduced activity or no remaining activity in activation of factor V and factor VIII, overview Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
selective cleavage of Arg-/-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B mechanism, modeling Homo sapiens
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-phenylalanyl-pipecolyl-L-arginine-4-nitroanilide + H2O i.e. S2238, synthetic chromogenic substrate Homo sapiens D-phenylalanyl-pipecolyl-L-arginine + 4-nitroaniline
-
 ?
fibrinogen + H2O
-
 Homo sapiens fibrin + fibrinopeptide A + fibrinopeptide B
-
 ?
additional information structural requirements for enzyme activity Homo sapiens ?
-
 ?
profactor V + H2O human, activation, recombinant Homo sapiens factor V
-
 ?
profactor VIII + H2O human, activation, recombinant Homo sapiens factor VIII
-
 ?
protein C + H2O
-
 Homo sapiens ?
-
 ?
thrombin-activatable fibrinolysis inhibitor + H2O i.e. TAFI Homo sapiens ?
-
 ?