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Literature summary for 3.4.21.49 extracted from
- Immunosuppressive effect of hypodermin C on complement component 3 in vitro (2015), Cell Biochem. Biophys., 72, 93-98 .
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | the enzyme may be used as immunosuppressive agent for the inhibition of the xenotransplant rejection | Hypoderma lineatum |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in COS-7 cells | Hypoderma lineatum |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Hypoderma lineatum | P08897 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| larva | - |
Hypoderma lineatum | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| guinea pig complement component C3 + H2O | - |
Hypoderma lineatum | ? | - |
? |  |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme is involved in the larval migration in the tissue and prevents the activation of the host immune response. The enzyme displays an immunosuppressive effect on complement component 3 in vitro | Hypoderma lineatum |
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