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Literature summary for 3.4.21.47 extracted from

  • Zwarthoff, S.A.; Berends, E.T.M.; Mol, S.; Ruyken, M.; Aerts, P.C.; Jozsi, M.; de Haas, C.J.C.; Rooijakkers, S.H.M.; Gorham, R.D.
    Functional characterization of alternative and classical pathway C3/C5 convertase activity and inhibition using purified models (2018), Front. Immunol., 9, 1691 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.47

Inhibitors

Inhibitors Comment Organism Structure
C4BP the inhibitor blocks both C3 and C5 conversion Homo sapiens
complement receptor of immunoglobulin family the inhibitor blocks both C3 and C5 conversion Homo sapiens
Cp40 the inhibitor blocks both C3 and C5 conversion Homo sapiens
eculizumab the inhibitor specifically interfers with C5 conversion but not C3 conversion Homo sapiens
Efb-C C-terminal region of extracellular fibrinogen binding protein. The inhibitor specifically blocks C5 conversion, while leaving C3 conversion unaffected Homo sapiens
extracellular complement binding protein the inhibitor specifically blocks C5 conversion, while leaving C3 conversion unaffected Homo sapiens
factor H the inhibitor blocks both C3 and C5 conversion Homo sapiens
factor H related-protein 5 inhibits C5 conversion in a concentration-dependent manner Homo sapiens
Ornithodoros moubata complement inhibitory protein the inhibitor specifically interfers with C5 conversion but not C3 conversion Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
complement component C3 + H2O Homo sapiens
-
 complement component C3a + complement component C3b
-
 ?
complement component C5 + H2O Homo sapiens
-
 complement component C5a + complement component C5b
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C3 + H2O
-
 Homo sapiens complement component C3a + complement component C3b
-
 ?
complement component C5 + H2O
-
 Homo sapiens complement component C5a + complement component C5b
-
 ?

Synonyms

Synonyms Comment Organism
alternative pathway C3/C5 convertase
-
 Homo sapiens
AP C3/C5 convertase
-
 Homo sapiens
C3bBb C3 convertase Homo sapiens
C3bBb(C3b)n C5 convertase Homo sapiens