Literature summary for 3.4.21.47 extracted from

Hourcade, D.E.; Mitchell, L.M.
Access to the complement factor B scissile bond is facilitated by association of factor B with C3b protein (2011), J. Biol. Chem., 286, 35725-35732.

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Protein Variants

Protein Variants	Comment	Organism
E207A	mutation in proenzyme factor B. Mutation disrupts salt bridge R234-E207, with little effects on the cleavage of proenzyme factor B	Homo sapiens
E446V	mutation in proenzyme factor B. Mutation disrupts salt bridge R234-E446 which partly stabilizes the complex C3bB(Mg2+) thereby inhibiting activation of the proenzyme	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

General Information

General Information	Comment	Organism
metabolism	when factor B first associates with C3b, it bears two intact Arg234 salt bridges. The complex rapidly dissociates unless the Arg234-Glu446 salt bridge is released whereupon conformational changes occur that activate the metal ion-dependent adhesion site and partially stabilize the complex. The remaining salt bridge is then released, exposing the scissile bond and permitting factor D cleavage of proenzyme factor B	Homo sapiens

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Release 2023.1 (January 2023)