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Literature summary for 3.4.21.47 extracted from
- IgG naturally occurring antibodies stabilize and promote the generation of the alternative complement pathway C3 convertase (2005), Mol. Immunol., 42, 1393-1403.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | patient with membranoproliferative glomerulonephritis, preparation of naturally occuring antibodies to enzyme exhibits nephritic factor activity 60fold stronger than total IgG. Antibodies promote enzyme generation, when added to the convertase precursor or during convertase assembly | Homo sapiens |
General Stability
| General Stability | Organism |
|---|---|
| marked stabilization of enzyme by naturally occuring IgG directed against the enzyme. Antibody prevents convertase decay in the presence of factor H. In addition, the antibody stabilizes enzyme precursors and promotes enzyme assembly | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
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Release 2023.1 (January 2023)
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