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Literature summary for 3.4.21.47 extracted from

  • Hourcade, D.E.; Mitchell, L.M.; Oglesby, T.J.
    A conserved element in the serine protease domain of complement factor B (1998), J. Biol. Chem., 273, 25996-26000.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
D715A factor B mutation, severly reduces hemolytic activity, in complex with C3b no cleavage of C3 Homo sapiens
D715E factor B mutation, severly reduces hemolytic activity, in complex with C3b no cleavage of C3 Homo sapiens
D715N factor B mutation, severly reduces hemolytic activity, in complex with C3b no cleavage of C3 Homo sapiens
D715S factor B mutation, severly reduces hemolytic activity Homo sapiens
D715Y factor B mutation, severly reduces hemolytic activity Homo sapiens
F716A factor B mutation, severly reduces hemolytic activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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