Application | Comment | Organism |
---|---|---|
medicine | PDGF-D is present in the neointima of the arteriopathy of chronic allograft nephropathy, where it can engage PDGF-Rbeta to promote mesenchymal cell migration, proliferation, and neointima formation. PDGF-D may engage the PDGF-Rbeta to promote interstitial injury in chronic allograft injury | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | PDGF-D is expressed uniformly in the cytoplasm of medial smooth muscle cells of the arteries and variably by some adventitial cells. PDGF-D expression is present in the epithelial cytoplasm of some, but not all, distal tubules and collecting ducts and in podocytes | Homo sapiens | 5737 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
artery | PDGF-D is widely expressed in most neointimas in arteries exhibiting the chronic arteriopathy of chronic allograft nephropathy and is only weakly expressed in a small proportion of sclerotic arteries. The neointimal cells expressing PDGF-D are alpha-smooth muscle actin-expressing cells, but not infiltrating macrophages or endothelial cells | Homo sapiens | - |
kidney | PDGF-D is uniformly expressed in visceral epithelial cells and arteriolar wall in normal kidneys, kidneys with acute vascular rejection, and kidneys with chronic allograft nephropathy. In kidneys with acute vascular rejection, PDGF-D is expressed in arterial medial smooth muscle cells, some adventitial cells, and some neointimal cells that also have alpha-smooth muscle actin expression | Homo sapiens | - |
additional information | present in distal tubule and duct. Absent from proximal tubule and interstitium | Homo sapiens | - |
podocyte | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
PDGF-D | - |
Homo sapiens |
platelet-derived growth factor D | - |
Homo sapiens |