Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.45 extracted from

  • Schlaf, G.; Rothermel, E.; Oppermann, M.; Schieferdecker, H.L.; Jungermann, K.
    Rat complement factor I: molecular cloning, sequencing and expression in tissue and isolated cells (1999), Immunology, 94, 464-474.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.45

Cloned(Commentary)

Cloned (Comment) Organism
-
 Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
28500
-
 1 * 28500 + 1 * 38000, calculation from nucleotide sequence Rattus norvegicus
38000
-
 1 * 28500 + 1 * 38000, calculation from nucleotide sequence Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
complement component C3b + H2O Rattus norvegicus cleavage of three peptide bonds in the alpha chain of complement component C3b, thereby inactivating this protein ?
-
 ?
complement component C4b + H2O Rattus norvegicus cleavage of two peptide bonds in the alpha chain of complement component C4b, thereby inactivating this protein ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
side-chain modification glycosylation of more than 20% of the total mass Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte only isolated hepatocytes but neither Kupffer cells, hepatic stellate cells or sinusoidal endothelial cells express FI-specific mRNA Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C3b + H2O cleavage of three peptide bonds in the alpha-chain of complement component C3b Rattus norvegicus complement component C3c + ?
-
 ?
complement component C3b + H2O cleavage of three peptide bonds in the alpha chain of complement component C3b, thereby inactivating this protein Rattus norvegicus ?
-
 ?
complement component C4b + H2O cleavage of two peptide bonds in the alpha chain of C4b Rattus norvegicus complement component C4c + C4d
-
 ?
complement component C4b + H2O cleavage of two peptide bonds in the alpha chain of complement component C4b, thereby inactivating this protein Rattus norvegicus ?
-
 ?

Subunits

Subunits Comment Organism
dimer 1 * 28500 + 1 * 38000, calculation from nucleotide sequence Rattus norvegicus