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Literature summary for 3.4.21.45 extracted from

  • Malm, S.; Jusko, M.; Eick, S.; Potempa, J.; Riesbeck, K.; Blom, A.M.
    Acquisition of complement inhibitor serine protease factor I and its cofactors C4b-binding protein and factor H by Prevotella intermedia (2012), PLoS ONE, 7, e34852.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.45

Activating Compound

Activating Compound Comment Organism Structure
C4b binding protein C4BP, required for activity, dependent on Homo sapiens
factor H required for activity, dependent on Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
complement component C3b + H2O Homo sapiens degradation in presence of C4b binding protein and factor H ?
-
 ?
complement component C4b + H2O Homo sapiens degradation in presence of C4b binding protein and factor H ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
extracellular enzyme from serum Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C3b + H2O degradation in presence of C4b binding protein and factor H Homo sapiens ?
-
 ?
complement component C4b + H2O degradation in presence of C4b binding protein and factor H Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
serine protease Factor I
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

General Information

General Information Comment Organism
additional information the enzyme can be selectively bound by Prevotella intermedia ATCC 25611 cells, the bound enzyme retains its serine protease activity, interaction analysis, overview Homo sapiens
physiological function the serine protease Factor I (FI) is the central inhibitor of complement degrading complement components C3b and C4b in the presence of cofactors such as C4b binding protein (C4BP) and factor H (FH). The selective enzyme binding by the bacterium Prevotella intermedia in human serum represents a distinct mechanism contributing to complement evasion by a Gram-negative bacterial pathogen associated with chronic diseases. Binding of enzyme cofactors C4BP and FH by Prevotella intermedia ATCC 25611 leads to increased degradation of C4b and C3b, respectively Homo sapiens