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Literature summary for 3.4.21.45 extracted from

  • Johnson, J.; Borisevich, V.; Rockx, B.; Parks, G.
    A novel factor I activity in Nipah virus inhibits human complement pathways through cleavage of C3b (2015), J. Virol., 89, 989-998.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.45

Activating Compound

Activating Compound Comment Organism Structure
complement component CR1 soluble, required for activity, dependent on Nipah henipavirus
factor H required for activity, dependent on Nipah henipavirus
additional information Nipah virus-dependent inactivation of C3b only occurs with the cofactors factor H and soluble CR1 but not with CD46 in vitro Nipah henipavirus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
complement component C3b + H2O Nipah henipavirus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Nipah henipavirus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information Nipah virus-associated factor I-like activity that cleaves C3b can be derived from the infected HeLa cells Nipah henipavirus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C3b + H2O Nipah virus-dependent inactivation of C3b only occurs with the cofactors factor H and soluble CR1 but not with CD46. When factor I is coupled with factor H, this cleavage can occur at two possible sites in the alpha' chain: R1281 and R1298, sites 1 and 2. In the presence of CR1, factor I can cleave the alpha' chain at sites 1 and 2 but also at an additional site at R932 Nipah henipavirus complement component iC3b + ?
-
 ?
complement component C3b + H2O
-
 Nipah henipavirus ?
-
 ?
additional information no activity with complement component C4b Nipah henipavirus ?
-
 ?

Synonyms

Synonyms Comment Organism
factor I
-
 Nipah henipavirus
factor I-like activity
-
 Nipah henipavirus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Nipah henipavirus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Nipah henipavirus

General Information

General Information Comment Organism
additional information the Nipah virus is completely resistant to in vitro neutralization by normal human serum Nipah henipavirus
physiological function the factor I activity in Nipah virus inhibits human complement pathways through cleavage of C3b Nipah henipavirus