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Literature summary for 3.4.21.45 extracted from
- Staphylococcus aureus clumping factor A binds to complement regulator factor I and increases factor I cleavage of C3b (2008), J. Infect. Dis., 198, 125-133.
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 88000 | - |
Western blotting | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| by size-exclusion chromatography | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood serum | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| complement component C3b + H2O | - |
Homo sapiens | inactivated C3b + ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| complement regulator factor I | - |
Homo sapiens |
| factor I | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| additional information | clumping factor A is shed from the surface of Staphylococcus aureus and binds to factor I. Recombinant clumping factor A and the shed clumping factor A fragment increase factor I cleavage of C3b. Cofactor activity increases in a dose-dependent manner | Homo sapiens |
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Release 2023.1 (January 2023)
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