Application | Comment | Organism |
---|---|---|
medicine | amyloid beta activates the complement system within drusen by blocking the function of factor I leading to a low-grade, chronic inflammation in subretinal tissues | Mus musculus |
medicine | amyloid beta activates the complement system within drusen by blocking the function of factor I leading to a low-grade, chronic inflammation in subretinal tissues | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
amyloid beta | binds to complement factor I which inhibits the ability of factor I to cleave C3b to inactivated C3b. Addition of factor I restores inactivated C3b production in amyloid beta-treated RPE cells. Preincubation of factor I with amyloid beta in the presence of factor H abolishes the ability of factor I to cleave FGR-7-amino-4-methylcoumarin | Homo sapiens | |
amyloid beta | production of inactivated C3b is significantly decreased when C3b and factor H are incubated with eyes from neprilysin gene-disrupted mice, which leads to an increased deposition of amyloid beta, compared with when C3b and factor H are incubated with eyes from wild-type mice | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
88000 | - |
coimmunoprecipitation analysis | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
eye | RPE-Bruch's membrane-choriocapillaris complex from eyes of 12-month-old neprilysin gene-disrupted mice and age-matched wild-type mice | Mus musculus | - |
additional information | RPE cell | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
complement component C3b + H2O | - |
Mus musculus | inactivated C3b + ? | - |
? | |
complement component C3b + H2O | factor I mediates cleavage of C3b between Arg1298 and Ser1299 | Homo sapiens | inactivated C3b + ? | - |
? | |
FGR-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | FGR + 7-amino-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
factor I | - |
Mus musculus |
factor I | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | factor H | Mus musculus | |
additional information | factor H | Homo sapiens |