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Literature summary for 3.4.21.43 extracted from
- A new function of the activated third component of complement: binding to C5, an essential step for C5 activation (1978), Immunology, 34, 29-40.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| complement component C3b | in inactive surface-fixed form essential for cleavage of C5 | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| complement component C5 + H2O | hydrolyzes peptide bond Arg77 of the alpha-chain of complement component C5, cleavage of C5 requires complement fragment C3b which binds C5 and renders it susceptible to cleavage by the C4b,C2a complex | Homo sapiens | complement component C5a + complement component C5b | - |
? |  |
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