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Literature summary for 3.4.21.43 extracted from

  • Zwarthoff, S.A.; Berends, E.T.M.; Mol, S.; Ruyken, M.; Aerts, P.C.; Jozsi, M.; de Haas, C.J.C.; Rooijakkers, S.H.M.; Gorham, R.D.
    Functional characterization of alternative and classical pathway C3/C5 convertase activity and inhibition using purified models (2018), Front. Immunol., 9, 1691 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.43

Inhibitors

Inhibitors Comment Organism Structure
C4BP effectively inhibits both C3 and C5 conversion Homo sapiens
complement receptor of immunoglobulin family inhibits C5 conversion specifically Homo sapiens
Cp40 the inhibitor shows potent inhibition of C3 conversion Homo sapiens
eculizumab potently inhibits C5 conversion but leaves C3 conversion unaffected Homo sapiens
Efb-C does not inhibit C3 convertase activity but C5 convertase activity Homo sapiens
extracellular complement binding protein does not inhibit C3 convertase activity but C5 convertase activity Homo sapiens
factor H inhibits C5 conversion specifically Homo sapiens
factor H related-protein 5 inhibits C5 conversion in a concentration-dependent manner Homo sapiens
Ornithodoros moubata complement inhibitory protein potently inhibits C5 conversion but leaves C3 conversion unaffected Homo sapiens
staphylococcal superantigen-like protein 7 inhibits C5 conversion Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
complement component C3 + H2O Homo sapiens
-
 complement component C3a + complement component C3b
-
 ?
complement component C5 + H2O Homo sapiens
-
 complement component C5a + complement component C5b
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C3 + H2O
-
 Homo sapiens complement component C3a + complement component C3b
-
 ?
complement component C5 + H2O
-
 Homo sapiens complement component C5a + complement component C5b
-
 ?

Synonyms

Synonyms Comment Organism
C4b2a C3 convertase Homo sapiens
C4b2a(C3b)n C5 convertase Homo sapiens
classical pathway C3/C5 convertase
-
 Homo sapiens
CP C3/C5 convertase
-
 Homo sapiens