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Literature summary for 3.4.21.43 extracted from

  • Laursen, N.S.; Gordon, N.; Hermans, S.; Lorenz, N.; Jackson, N.; Wines, B.; Spillner, E.; Christensen, J.B.; Jensen, M.; Fredslund, F.; Bjerre, M.; Sottrup-Jensen, L.; Fraser, J.D.; Andersen, G.R.
    Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus (2010), Proc. Natl. Acad. Sci. USA, 107, 3681-3686.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
OmCI the inhibitor blocks C5 cleavage by interfering with convertase recognition far from C5a Homo sapiens
SSL7 the inhibitor blocks C5 cleavage by interfering with convertase recognition far from C5a Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C5 + H2O
-
 Homo sapiens complement component C5a + complement component C5b
-
 ?

Synonyms

Synonyms Comment Organism
C4b2a3b
-
 Homo sapiens
classical pathway C5 convertase
-
 Homo sapiens