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Literature summary for 3.4.21.43 extracted from

  • Katschke, K.J.; Stawicki, S.; Yin, J.; Steffek, M.; Xi, H.; Sturgeon, L.; Hass, P.E.; Loyet, K.M.; Deforge, L.; Wu, Y.; van Lookeren Campagne, M.; Wiesmann, C.
    Structural and functional analysis of a C3b-specific antibody that selectively inhibits the alternative pathway of complement (2009), J. Biol. Chem., 284, 10473-10479.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
additional information the C3b-specific antibody fragment S77 does not inhibit the classical pathway C5 convertase in human serum Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C5 + H2O
-
 Homo sapiens complement component C5a + complement component C5b
-
 ?

Synonyms

Synonyms Comment Organism
classical pathway C5 convertase
-
 Homo sapiens
CP C5 convertase
-
 Homo sapiens