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Literature summary for 3.4.21.43 extracted from

  • Spiller, O.B.; Mark, L.; Blue, C.E.; Proctor, D.G.; Aitken, J.A.; Blom, A.M.; Blackbourn, D.J.
    Dissecting the regions of virion-associated Kaposis sarcoma-associated herpesvirus complement control protein required for complement regulation and cell binding (2006), J. Virol., 80, 4068-4078.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
complement component C5 + H2O Homo sapiens C5 convertases, C4b2a3b and C3b2Bb, cleave C5 into the anaphylatoxin C5a and C5b, overview complement component C5a + complement component C5b
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 ?
complement componentC3 + H2O Homo sapiens C3 convertases, C4b2a and C3bBb, cleave C3 into the anaphylatoxin C3a and C3b, overview complement component C3a + complement component C3b
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 ?
additional information Homo sapiens the virion-associated Kaposis sarcoma-associated herpesvirus complement control protein is required for complement regulation and cell binding, involved structures, Kaposi’s sarcoma-associated herpesvirus, KSHV, encodes a lytic cycle protein called KSHV complement control protein, KCP, that inhibits activation of the complement cascade. It does so by regulating C3 convertases, accelerating their decay, and acting as a cofactor for factor I degradation of C4b and C3b, two components of the C3 and C5 convertases, KCP is expressed on the surface of human infected endothelial cells, mechanism, overview, K64Q/K65Q/K88Q KCP mutant lacks complement regulatory activity ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C5 + H2O C5 convertases, C4b2a3b and C3b2Bb, cleave C5 into the anaphylatoxin C5a and C5b, overview Homo sapiens complement component C5a + complement component C5b
-
 ?
complement componentC3 + H2O C3 convertases, C4b2a and C3bBb, cleave C3 into the anaphylatoxin C3a and C3b, overview Homo sapiens complement component C3a + complement component C3b
-
 ?
additional information the virion-associated Kaposis sarcoma-associated herpesvirus complement control protein is required for complement regulation and cell binding, involved structures, Kaposi’s sarcoma-associated herpesvirus, KSHV, encodes a lytic cycle protein called KSHV complement control protein, KCP, that inhibits activation of the complement cascade. It does so by regulating C3 convertases, accelerating their decay, and acting as a cofactor for factor I degradation of C4b and C3b, two components of the C3 and C5 convertases, KCP is expressed on the surface of human infected endothelial cells, mechanism, overview, K64Q/K65Q/K88Q KCP mutant lacks complement regulatory activity Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
C3 convertase
-
 Homo sapiens
C3b2Bb
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 Homo sapiens
C3bBb
-
 Homo sapiens
C4b2a
-
 Homo sapiens
C4b2a3b
-
 Homo sapiens
C5 convertase
-
 Homo sapiens