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Literature summary for 3.4.21.43 extracted from

  • Jongerius, I.; Koehl, J.; Pandey, M.K.; Ruyken, M.; van Kessel, K.P.; van Strijp, J.A.; Rooijakkers, S.H.
    Staphylococcal complement evasion by various convertase-blocking molecules (2007), J. Exp. Med., 204, 2461-2471.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.43

Inhibitors

Inhibitors Comment Organism Structure
extracellular complement-binding protein Ecb, a potent complement inhibitor from Staphylococcus aureus, with strong antiinflammatory properties, inhibitory mechanism for blocking C3b-containing convertases, Efb-C and Ecb act on the bacterial surface, overview Homo sapiens
extracellular fibrinogen-binding protein Efb, a potent complement inhibitor from Staphylococcus aureus, with strong antiinflammatory properties, inhibitory mechanism for blocking C3b-containing convertases, Efb-C and Ecb act on the bacterial surface, overview Homo sapiens
staphylococcal complement inhibitor SCIN, a potent complement inhibitor from Staphylococcus aureus, with strong antiinflammatory properties, inhibitory mechanism for blocking C3b-containing convertases, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
complement component C5 + H2O Homo sapiens C5 convertases C4b2aC3b and C3b 2 Bb complement component C5a + complement component C5b
-
 ?
complement componentC3 + H2O Homo sapiens C3 convertase C3bBb complement component C3a + complement component C3b
-
 ?
additional information Homo sapiens the alternative pathway lead via C3 convertase C3bBb and the C5 convertases C4b2aC3b and C3b 2 Bb ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C5 + H2O C5 convertases C4b2aC3b and C3b 2 Bb Homo sapiens complement component C5a + complement component C5b
-
 ?
complement componentC3 + H2O C3 convertase C3bBb Homo sapiens complement component C3a + complement component C3b
-
 ?
additional information the alternative pathway lead via C3 convertase C3bBb and the C5 convertases C4b2aC3b and C3b 2 Bb Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
C3 convertase
-
 Homo sapiens
C3b 2 Bb
-
 Homo sapiens
C3bBb
-
 Homo sapiens
C4b2aC3b
-
 Homo sapiens
C5 convertase
-
 Homo sapiens