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Literature summary for 3.4.21.42 extracted from
- Potentiation of C1-esterase inhibitor by heparin and interactions with C1s protease as assessed by surface plasmon resonance (2011), Biochim. Biophys. Acta, 1820, 56-63.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| C1-esterase inhibitor | inhibitory effect is increased by addition of heparin (5-500 nM) | Homo sapiens | |
| human C1-esterase inhibitor | C1-INH, a multifunctional plasma protein with a wide range of inhibitory and non-inhibitory properties, mainly recognized as a key downregulator of the complement and contact cascades. Potentiation of C1-INH by heparin and other glycosaminoglycans regulating a broad spectrum of C1-INH activities in vivo both in normal and disease states, interaction analysis via double capture SPR approach, surface plasmon resonance (using a CM5 sensor chip through amine coupling) and circular dichroism, overview. Heparin binding does not alter C1-INH secondary structure and does not affect the amidolytic activity of C1s, but does accelerate its consumption due to C1-INH potentiation | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetics in presence of inhibitor, overview | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Homo sapiens | P09871 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| commercial preparation | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| C2H5CO-Lys-(epsilon-Cbz)-Gly-Arg-4-nitroanilide + H2O | - |
Homo sapiens | C2H5CO-Lys-(epsilon-Cbz)-Gly-Arg + 4-nitroaniline | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| C1s protease | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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