Literature summary for 3.4.21.42 extracted from

Busby, W.H.; Yocum, S.A.; Rowland, M.; Kellner, D.; Lazerwith, S.; Sverdrup, F.; Yates, M.; Radabaugh, M.; Clemmons, D.R.
Complement 1s is the serine protease that cleaves IGFBP-5 in human osteoarthritic joint fluid (2009), Osteoarthritis Cartilage, 17, 547-555.

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Inhibitors

Inhibitors	Comment	Organism	Structure
1,10-phenanthroline	-	Homo sapiens
CP-013043	-	Homo sapiens
CP-143217	-	Homo sapiens
CP-349547	-	Homo sapiens
FUT175	potent C1s inhibitor	Homo sapiens
PHA-00737785	-	Homo sapiens
serine protease inhibitor 1	-	Homo sapiens
serine protease inhibitor 2	-	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
86000	-	1 * 88000 ,immunoblotting, both joint fluid and purified material, 1 * 90000, SDS-PAGE and 1 * 86000, SDS-PAGE	Homo sapiens
88000	-	1 * 88000 ,immunoblotting, both joint fluid and purified material, 1 * 90000, SDS-PAGE and 1 * 86000, SDS-PAGE	Homo sapiens
90000	-	1 * 88000 ,immunoblotting, both joint fluid and purified material, 1 * 90000, SDS-PAGE and 1 * 86000, SDS-PAGE	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
by gel filtration and on affinity column	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
insulin-like growth factor-I binding protein-5 + H2O	C1s accounts for the proteolytic activity in human osteoarthritis fluid for insulin-like growth factor-I binding protein-5	Homo sapiens	?	-	?

Subunits

Subunits	Comment	Organism
monomer	1 * 88000 ,immunoblotting, both joint fluid and purified material, 1 * 90000, SDS-PAGE and 1 * 86000, SDS-PAGE	Homo sapiens

Synonyms

Synonyms	Comment	Organism
C1s	-	Homo sapiens
complement 1s	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00007	-	-	Homo sapiens	CP-143217
0.001	-	-	Homo sapiens	CP-349547
0.001	-	-	Homo sapiens	CP-013043
0.0103	-	-	Homo sapiens	PHA-00737785
0.1	-	-	Homo sapiens	1,10-phenanthroline
0.1	-	-	Homo sapiens	FUT175
0.1	-	-	Homo sapiens	serine protease inhibitor 1
0.1	-	-	Homo sapiens	serine protease inhibitor 2

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Release 2023.1 (January 2023)