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Literature summary for 3.4.21.42 extracted from
- Cooperative effects in the substrate specificity of the complement protease C1s (2009), Biol. Chem., 390, 503-507.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | requirement by C1s for arginine at the P1 position. Pronounced cooperativity between the S4 and S1' subsites in the active site of the enzyme, and weaker cooperativity between the S1' and S3' subsites | unidentified |
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | further probing for cooperativity may be of great value in the development of a peptide inhibitor for the C1s protease in the treatment of inflammatory disease | unidentified |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| unidentified | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| complement protease C1s | - |
unidentified |
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