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Literature summary for 3.4.21.41 extracted from

  • Bally, I.; Ancelet, S.; Moriscot, C.; Gonnet, F.; Mantovani, A.; Daniel, R.; Schoehn, G.; Arlaud, G.J.; Thielens, N.M.
    Expression of recombinant human complement C1q allows identification of the C1r/C1s-binding sites (2013), Proc. Natl. Acad. Sci. USA, 110, 8650-8655.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.41

Cloned(Commentary)

Cloned (Comment) Organism
development and evaluation of a method for expression of recombinant full-length human C-terminally tagged C1q involving stable transfection of HEK 293-F mammalian cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
complement C1q zymogen + H2O Homo sapiens
-
 active complement C1q + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P00736
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood serum
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement C1q zymogen + H2O
-
 Homo sapiens active complement C1q + ?
-
 ?
complement C1q zymogen + H2O no or reduced activity with substrate mutants K59A, K61A, K58A, and K58A/K59A/K61A Homo sapiens active complement C1q + ?
-
 ?

Synonyms

Synonyms Comment Organism
proteases C1r
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

General Information

General Information Comment Organism
metabolism hexameric complement C1q is a versatile recognition protein that senses a wide variety of immune and nonimmune ligands, including pathogens and altered self components, and triggers the classical complement pathway through activation of its associated proteases C1r and C1s, EC 3.4.21.42. Residues LysB61 and LysC58 each play a key role in the interaction with C1s-C1r-C1r-C1s, with LysA59 being involved to a lesser degree Homo sapiens