Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Sus scrofa | - |
pancreas | - |
Sus scrofa | - |
General Information | Comment | Organism |
---|---|---|
physiological function | trypsin activates PAR4 null murine platelets. Trypsin causes shape change without increasing intracellular calcium levels in PAR4 null murine platelets. Trypsin-induced platelet shape change is abolished by either p160ROCK inhibitor, Y27632 or H1152. Trypsin causes phosphorylation of myosin light chain (Thr18), but not Akt or Erk. Trypsin causes a similar shape change in PAR4-desensitized PAR3 null murine platelets as in PAR4 null murine platelets, indicating that trypsin does not activate PAR3 to cause shape change. The Src family kinase inhibitor PP2 abolishes trypsin-induced, but not AYPGKF-induced, shape change | Sus scrofa |