Any feedback?
Literature summary for 3.4.21.39 extracted from
- Mast cell chymase and tryptase in abdominal aortic aneurysm formation (2012), Trends Cardiovasc. Med., 22, 150-155.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| NK3201 | - |
Homo sapiens |  |
| SF-8257 | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| angiotensin I + H2O | Homo sapiens | - |
angiotensin II + His-Leu | - |
? | |
| pro-collagen + H2O | Homo sapiens | - |
collagen + ? | - |
? | |
| pro-matrix metalloproteinase-1 + H2O | Homo sapiens | - |
matrix metalloproteinase-1 + ? | - |
? | |
| pro-matrix metalloproteinase-3 + H2O | Homo sapiens | - |
matrix metalloproteinase-3 + ? | - |
? | |
| Vitronectin + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P23946 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| mast cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| angiotensin I + H2O | - |
Homo sapiens | angiotensin II + His-Leu | - |
? | |
| pro-collagen + H2O | - |
Homo sapiens | collagen + ? | - |
? | |
| pro-matrix metalloproteinase-1 + H2O | - |
Homo sapiens | matrix metalloproteinase-1 + ? | - |
? | |
| pro-matrix metalloproteinase-3 + H2O | - |
Homo sapiens | matrix metalloproteinase-3 + ? | - |
? | |
| Vitronectin + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| mast cell chymase | - |
Homo sapiens |
| MC chymase | - |
Homo sapiens |
| MC-specific chymase | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | chymase is increased in AAA lesions, and in blood from AAA patients | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | chymase deficiency reduces abdominal aortic aneurysm lesion angiogenesis or in vitro microvessel growth | Homo sapiens |
| physiological function | the enzyme indirectly influences abdominal aortic aneurysm formation | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
