Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin I + H2O | Rattus norvegicus | - |
angiotensin II + His-Leu | - |
? | |
endothelin-1 + H2O | Rattus norvegicus | - |
31 amino-acid fragment of ET-1 + ? | - |
? | |
interleukin-18 + H2O | Rattus norvegicus | - |
? | - |
? | |
interleukin-1beta + H2O | Rattus norvegicus | - |
? | - |
? | |
procollagen + H2O | Rattus norvegicus | - |
collagen + ? | - |
? | |
transforming growth factor beta-binding protein + H2O | Rattus norvegicus | - |
transforming growth factor beta + protein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
mast cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin I + H2O | - |
Rattus norvegicus | angiotensin II + His-Leu | - |
? | |
endothelin-1 + H2O | - |
Rattus norvegicus | 31 amino-acid fragment of ET-1 + ? | - |
? | |
interleukin-18 + H2O | - |
Rattus norvegicus | ? | - |
? | |
interleukin-1beta + H2O | - |
Rattus norvegicus | ? | - |
? | |
procollagen + H2O | - |
Rattus norvegicus | collagen + ? | - |
? | |
transforming growth factor beta-binding protein + H2O | - |
Rattus norvegicus | transforming growth factor beta + protein | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MC chymase | - |
Rattus norvegicus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
7 | 9 | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme is involved in the process of pulmonary fibrosis. The enzyme has a role in connecting matrix metalloproteinases (MMPs), particularly the gelatinases MMP-2 and MMP-9, to pulmonary fibrosis. Mast cell chymase by processing angiotensin II and transforming growth factor beta contributes to the development of idiopathic pulmonary fibrosis | Rattus norvegicus |