Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.39 extracted from

  • Simard, E.; Jin, D.; Takai, S.; Miyazaki, M.; Brochu, I.; DOrleans-Juste, P.
    Chymase-dependent conversion of Big endothelin-1 in the mouse in vivo (2009), J. Pharmacol. Exp. Ther., 328, 540-548.
    View publication on PubMed
Search for more literature for 3.4.21.39

Inhibitors

Inhibitors Comment Organism Structure
chymostatin [(S)-1-carboxy-2-phenylethyl]-carbamoyl-alpha-[2-iminohexahydro-4(S)-pyrimidyl]-(S)-Gly-X-Phe-al, X can be the amino acid Leu, Val, or Ile, nonspecific chymase inhibitor Mus musculus
additional information not inhibited by phosphoramidon Mus musculus
Suc-Val-Pro-PheP-(OPh)2 specific chymase inhibitor Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Big endothelin-1 + H2O Mus musculus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta
-
 Mus musculus
-
heart
-
 Mus musculus
-
lung
-
 Mus musculus
-
mucosa
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Big endothelin-1 + H2O
-
 Mus musculus ?
-
 ?
succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O
-
 Mus musculus succinyl-Leu-Leu-Val-Tyr + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
mast cell chymases 4
-
 Mus musculus
MCP-4 MCP-4 is a beta-chymase Mus musculus