Literature summary for 3.4.21.39 extracted from

Omoto, Y.; Tokime, K.; Yamanaka, K.; Habe, K.; Morioka, T.; Kurokawa, I.; Tsutsui, H.; Yamanishi, K.; Nakanishi, K.; Mizutani, H.
Human mast cell chymase cleaves pro-IL-18 and generates a novel and biologically active IL-18 fragment (2006), J. Immunol., 177, 8315-8319.

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Inhibitors

Inhibitors	Comment	Organism	Structure
antichymotrypsin	-	Homo sapiens
antitrypsin	-	Homo sapiens
additional information	not affected by heparin	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Homo sapiens	5737	-
mast cell granule	-	Homo sapiens	42629	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
mast cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
pro-interleukin-18 + H2O	cleaves recombinant pro-interleukin-18 at 56-Phe	Homo sapiens	interleukin-18 fragments	16 and 20 kDa fragments, the 16 kDa fragment is biologically active	?

Synonyms

Synonyms	Comment	Organism
alpha-chymase	-	Homo sapiens
mast cell protease	-	Homo sapiens

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Release 2023.1 (January 2023)