Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(6E)-4-[(4-chlorophenyl)sulfonyl]-6-(phenylmethylidene)-1,4-diazepane-2,5-dione | - |
Homo sapiens | |
(6R)-6-(5-chloro-2-methoxybenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione | - |
Homo sapiens | |
(6S)-6-(5-chloro-2-methoxybenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione | potent inhibitor | Homo sapiens | |
2-[4-chloro-2-([1-[(4-chlorophenyl)sulfonyl]-3,7-dioxo-1,4-diazepan-6-yl]methyl)phenoxy]-N-methylacetamide | - |
Homo sapiens | |
3-([1-[(4-chlorophenyl)sulfonyl]-3,7-dioxo-1,4-diazepan-6-yl]methyl)-4-methoxybenzonitrile | - |
Homo sapiens | |
4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione | - |
Homo sapiens | |
4-[(4-chlorophenyl)sulfonyl]-6-(2,5-dimethoxybenzyl)-1,4-diazepane-2,5-dione | - |
Homo sapiens | |
4-[(4-chlorophenyl)sulfonyl]-6-(2-ethoxybenzyl)-1,4-diazepane-2,5-dione | - |
Homo sapiens | |
4-[(4-chlorophenyl)sulfonyl]-6-(2-fluorobenzyl)-1,4-diazepane-2,5-dione | - |
Homo sapiens | |
4-[(4-chlorophenyl)sulfonyl]-6-(2-methoxybenzyl)-1,4-diazepane-2,5-dione | - |
Homo sapiens | |
4-[(4-chlorophenyl)sulfonyl]-6-(4,5-dichloro-2-methoxybenzyl)-1,4-diazepane-2,5-dione | - |
Homo sapiens | |
4-[(4-chlorophenyl)sulfonyl]-6-(5-chloro-2-propoxybenzyl)-1,4-diazepane-2,5-dione | - |
Homo sapiens | |
4-[(4-chlorophenyl)sulfonyl]-6-(5-fluoro-2-methoxybenzyl)-1,4-diazepane-2,5-dione | - |
Homo sapiens | |
4-[(4-chlorophenyl)sulfonyl]-6-(5-hydroxy-2-methoxybenzyl)-1,4-diazepane-2,5-dione | - |
Homo sapiens | |
4-[(4-chlorophenyl)sulfonyl]-6-(cyclohexylmethyl)-1,4-diazepane-2,5-dione | - |
Homo sapiens | |
4-[(4-chlorophenyl)sulfonyl]-6-(naphthalen-2-ylmethyl)-1,4-diazepane-2,5-dione | - |
Homo sapiens | |
4-[(4-chlorophenyl)sulfonyl]-6-(pyridin-3-ylmethyl)-1,4-diazepane-2,5-dione | - |
Homo sapiens | |
4-[(4-chlorophenyl)sulfonyl]-6-(pyridin-4-ylmethyl)-1,4-diazepane-2,5-dione | - |
Homo sapiens | |
6-(2-butoxy-5-chlorobenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione | - |
Homo sapiens | |
6-(2-chlorobenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione | - |
Homo sapiens | |
6-(3-chloro-5-fluoro-2-methoxybenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione | - |
Homo sapiens | |
6-(3-chlorobenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione | - |
Homo sapiens | |
6-(4-chlorobenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione | - |
Homo sapiens | |
6-(5-chloro-2-ethoxybenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione | - |
Homo sapiens | |
6-(5-chloro-2-methoxybenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione | - |
Homo sapiens | |
6-benzyl-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione | - |
Homo sapiens | |
chymostatin | - |
Homo sapiens | |
[4-chloro-2-([1-[(4-chlorophenyl)sulfonyl]-3,7-dioxo-1,4-diazepan-6-yl]methyl)phenoxy]acetic acid | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
mast cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin I + H2O | - |
Homo sapiens | angiotensin II + ? | - |
? | |
succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O | - |
Homo sapiens | succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000018 | - |
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100 | Homo sapiens | 4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione | |
0.000023 | - |
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100 | Homo sapiens | 4-[(4-chlorophenyl)sulfonyl]-6-(4,5-dichloro-2-methoxybenzyl)-1,4-diazepane-2,5-dione | |
0.000026 | - |
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100 | Homo sapiens | 4-[(4-chlorophenyl)sulfonyl]-6-(5-fluoro-2-methoxybenzyl)-1,4-diazepane-2,5-dione | |
0.000027 | - |
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100 | Homo sapiens | 3-([1-[(4-chlorophenyl)sulfonyl]-3,7-dioxo-1,4-diazepan-6-yl]methyl)-4-methoxybenzonitrile | |
0.000027 | - |
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100 | Homo sapiens | (6S)-6-(5-chloro-2-methoxybenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione | |
0.000034 | - |
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100 | Homo sapiens | 6-(5-chloro-2-methoxybenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione | |
0.000039 | - |
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100 | Homo sapiens | [4-chloro-2-([1-[(4-chlorophenyl)sulfonyl]-3,7-dioxo-1,4-diazepan-6-yl]methyl)phenoxy]acetic acid | |
0.000042 | - |
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100 | Homo sapiens | 2-[4-chloro-2-([1-[(4-chlorophenyl)sulfonyl]-3,7-dioxo-1,4-diazepan-6-yl]methyl)phenoxy]-N-methylacetamide | |
0.000043 | - |
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100 | Homo sapiens | chymostatin | |
0.000083 | - |
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100 | Homo sapiens | 6-(5-chloro-2-ethoxybenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione | |
0.00011 | - |
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100 | Homo sapiens | 6-(2-chlorobenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione | |
0.00014 | - |
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100 | Homo sapiens | 4-[(4-chlorophenyl)sulfonyl]-6-(2-methoxybenzyl)-1,4-diazepane-2,5-dione | |
0.00015 | - |
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100 | Homo sapiens | 4-[(4-chlorophenyl)sulfonyl]-6-(2-fluorobenzyl)-1,4-diazepane-2,5-dione | |
0.00018 | - |
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100 | Homo sapiens | 4-[(4-chlorophenyl)sulfonyl]-6-(2-ethoxybenzyl)-1,4-diazepane-2,5-dione | |
0.00022 | - |
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100 | Homo sapiens | 4-[(4-chlorophenyl)sulfonyl]-6-(5-chloro-2-propoxybenzyl)-1,4-diazepane-2,5-dione | |
0.00028 | - |
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100 | Homo sapiens | 6-(2-butoxy-5-chlorobenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione | |
0.00031 | - |
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100 | Homo sapiens | 6-(3-chlorobenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione | |
0.00042 | - |
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100 | Homo sapiens | 6-benzyl-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione | |
0.00046 | - |
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100 | Homo sapiens | 6-(4-chlorobenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione | |
0.0011 | - |
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100 | Homo sapiens | 4-[(4-chlorophenyl)sulfonyl]-6-(5-hydroxy-2-methoxybenzyl)-1,4-diazepane-2,5-dione | |
0.0015 | - |
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100 | Homo sapiens | (6E)-4-[(4-chlorophenyl)sulfonyl]-6-(phenylmethylidene)-1,4-diazepane-2,5-dione | |
0.0042 | - |
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100 | Homo sapiens | 6-(3-chloro-5-fluoro-2-methoxybenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione | |
0.0074 | - |
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100 | Homo sapiens | 4-[(4-chlorophenyl)sulfonyl]-6-(2,5-dimethoxybenzyl)-1,4-diazepane-2,5-dione | |
0.01 | - |
IC50 above 0.01 mM, in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100 | Homo sapiens | 4-[(4-chlorophenyl)sulfonyl]-6-(cyclohexylmethyl)-1,4-diazepane-2,5-dione | |
0.01 | - |
IC50 above 0.01 mM, in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100 | Homo sapiens | 4-[(4-chlorophenyl)sulfonyl]-6-(naphthalen-2-ylmethyl)-1,4-diazepane-2,5-dione | |
0.01 | - |
IC50 above 0.01 mM, in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100 | Homo sapiens | 4-[(4-chlorophenyl)sulfonyl]-6-(pyridin-3-ylmethyl)-1,4-diazepane-2,5-dione | |
0.01 | - |
IC50 above 0.01 mM, in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100 | Homo sapiens | 4-[(4-chlorophenyl)sulfonyl]-6-(pyridin-4-ylmethyl)-1,4-diazepane-2,5-dione | |
0.01 | - |
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100 | Homo sapiens | (6R)-6-(5-chloro-2-methoxybenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione |