Literature summary for 3.4.21.39 extracted from

Schiemann, F.; Grimm, T.A.; Hoch, J.; Gross, R.; Lindner, B.; Petersen, F.; Bulfone-Paus, S.; Brandt, E.
Mast cells and neutrophils proteolytically activate chemokine precursor CTAP-III and are subject to counterregulation by PF-4 through inhibition of chymase and cathepsin G (2006), Blood, 107, 2234-2242.

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Inhibitors

Inhibitors	Comment	Organism	Structure
platelet factor 4	i.e. PF-4, competitive inhibition of enzyme and cathepsin G	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
mast cell	activated skin mast cell	Homo sapiens	-
skin	activated skin mast cell	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
connective tissue-activating peptide III + H2O	i.e. CTAP-II	Homo sapiens	neutrophil-activating peptide 2 + precursorpeptide	i.e. NAP-2	?

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Release 2023.1 (January 2023)