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Literature summary for 3.4.21.38 extracted from

  • Wang, R.; Zhang, T.; Ma, Z.; Wang, Y.; Cheng, Z.; Xu, H.; Li, W.; Wang, X.
    The interaction of coagulation factor XII and monocyte/macrophages mediating peritoneal metastasis of epithelial ovarian cancer (2010), Gynecol. Oncol., 117, 460-466.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelial ovarian cancer cell
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Homo sapiens
-
ES-2 cell
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Homo sapiens
-
SKOV-3 cell
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Homo sapiens
-

Synonyms

Synonyms Comment Organism
coagulation factor XII
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Homo sapiens
FXII
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Homo sapiens

General Information

General Information Comment Organism
malfunction interaction between FXII and monocyte/macrophages contributes to epithelial ovarian cancer cell invasion and metastasis of the peritoneum. After FXII treatment the cells exhibited M2-polarized phenotypes and show upregulated phagocytic potential. Transcription factors including Fra-1, Fra-2, Fos-B in the AP-1 family, oncogenes HIF-1 and Oct, and STAT-5A in the STAT family are upregulated in FXII-stimulated monocyte/macrophages Homo sapiens