Literature summary for 3.4.21.37 extracted from

Hansen, G.; Gielen-Haertwig, H.; Reinemer, P.; Schomburg, D.; Harrenga, A.; Niefind, K.
Unexpected active-site flexibility in the structure of human neutrophil elastase in complex with a new dihydropyrimidone inhibitor (2011), J. Mol. Biol., 409, 681-691.

Search for more literature for 3.4.21.37

Application

Application	Comment	Organism
medicine	neutrophil elastase is a major target for the development of compounds that inhibit the progression of long-term lung function decline in chronic obstructive pulmonary disease patients	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
in complex with dihydropyrimidone inhibitor, sitting drop vapor diffusion method, using 20% (w/v) PEG 3350 and 0.2 M ammonium citrate (pH 5.0) or uncomplexed enzyme, sitting drop vapor diffusion method, using 1.9 M ammonium sulfate, 5% (w/v) PEG 400, 0.1 M 4-morpholine ethanesulfonic acid/NaOH (pH 6.5), and 20% (v/v) glycerol	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
2-hydroxyethyl (4R)-4-[4-cyanophenyl-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]]-1,2,3,4-tetrahydropyrimidine-5-carboxylate	-	Homo sapiens
GW475151	suicide inhibitor	Homo sapiens
MDL101146	suicide inhibitor	Homo sapiens
MeO-Suc-Ala-Ala-Pro-Ala-CH2Cl	suicide inhibitor	Homo sapiens
MeO-Suc-Ala-Ala-Pro-Val-CH2Cl	suicide inhibitor	Homo sapiens
OMTKY3	-	Homo sapiens
SLPI	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P08246	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
HNE	-	Homo sapiens
neutrophil elastase	-	Homo sapiens
neutrophil-released elastase	-	Homo sapiens

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Release 2023.1 (January 2023)