Literature summary for 3.4.21.37 extracted from

Hahn, I.; Klaus, A.; Janze, A.K.; Steinwede, K.; Ding, N.; Bohling, J.; Brumshagen, C.; Serrano, H.; Gauthier, F.; Paton, J.C.; Welte, T.; Maus, U.A.
Cathepsin G and neutrophil elastase play critical and nonredundant roles in lung-protective immunity against Streptococcus pneumoniae in mice (2011), Infect. Immun., 79, 4893-4901.

Search for more literature for 3.4.21.37

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Abz-QPMAVVQSVPQ-EDDnp + H2O	-	Mus musculus	?	-	?

Synonyms

Synonyms	Comment	Organism
neutrophil elastase	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	neutrophil elastase knockout mice respond with increased lung permeability to infection with Streptococcus pneumoniae, resulting in severe respiratory distress and progressive mortality. Ablation of hematopoietic neutrophil elastase in bone marrow chimeras abolishes intra-alveolar neutrophil elastase immunoreactivity and leads to bacterial outgrowth in the lungs of mice	Mus musculus
physiological function	neutrophil elastase plays a critical and nonredundant role in lung-protective immunity against Streptococcus pneumoniae in mice	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)