Inhibitors | Comment | Organism | Structure |
---|---|---|---|
L-658758 | the neutrophil elastase inhibitor prevents ischemia/reperfusion-induced decreases of hepatic tissue levels of CGRP and IGF-I | Rattus norvegicus | |
sivelestat | the neutrophil elastase inhibitor prevents ischemia/reperfusion-induced decreases of hepatic tissue levels of CGRP and IGF-I | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male Wistar rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
neutrophil | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
neutrophil elastase | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | neutrophil elastase decreases the endothelial production of prostacyclin through the inhibition of endothelial nitric oxide synthase activation and thereby contributes to the development of ischemia/reperfusion-induced liver injury. Neutrophil elastase may play a critical role in the development of I/R-induced liver injury by decreasing the IGF-I production through the inhibition of sensory neuron stimulation, which may lead to an increase of neutrophil accumulation and hepatic apoptosis through activation of caspase-3 in rats, overview | Rattus norvegicus |