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Literature summary for 3.4.21.37 extracted from

  • Jackson, P.L.; Xu, X.; Wilson, L.; Weathington, N.M.; Clancy, J.P.; Blalock, J.E.; Gaggar, A.
    Human neutrophil elastase-mediated cleavage sites of MMP-9 and TIMP-1: implications to cystic fibrosis proteolytic dysfunction (2010), Mol. Med., 16, 159-166.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.37

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
neutrophil from peripheral blood Homo sapiens
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sputum from cystic fibrosis patients Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
matrix metalloprotease 9 + H2O i.e. MMP-9, neutrophil elastase cleaves and activates at two specific cleavage sites, between Val38 and Ala39, and between Ala 39 and Glu40 Homo sapiens matrix metalloprotease 9 peptide fragments
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 ?
additional information nano-LC tandem mass spectrometry neutrophil elastase cleavage site identification, overview Homo sapiens ?
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 ?
N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
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 Homo sapiens N-methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline
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 ?
tissue inhibitor of metalloprotease-1 + H2O i.e. TIMP-1, neutrophil elastase degrades TIMP-1 and cleaves between Val69-Cys70 Homo sapiens tissue inhibitor of metalloprotease-1 peptide fragments
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 ?

Synonyms

Synonyms Comment Organism
neutrophil elastase
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 Homo sapiens