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Literature summary for 3.4.21.37 extracted from

  • Duvoix, A.; Mackay, R.M.; Henderson, N.; McGreal, E.; Postle, A.; Reid, K.; Clark, H.
    Physiological concentration of calcium inhibits elastase-induced cleavage of a functional recombinant fragment of surfactant protein D (2010), Immunobiology, 216, 72-79.
    View publication on PubMed
Search for more literature for 3.4.21.37

Inhibitors

Inhibitors Comment Organism Structure
Ca2+ inhibition of human SP-D protein cleavage at physiological concentrations Pseudomonas aeruginosa

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ inhibition of SP-D protein cleavage at physiological concentrations Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
human SP-D protein + H2O Pseudomonas aeruginosa cleavage in the lungs of the cystic fibrosis human host, but not in helathy human hosts SP-D protein peptide fragments cleavage product identification by N-terminal sequencing, overview ?
SP-D protein + H2O Homo sapiens no activity in healthy lungs, but in 50% of cystic fibrosis patient lungs SP-D protein peptide fragments cleavage product identification by N-terminal sequencing, overview ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Pseudomonas aeruginosa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bronchoalveolar lavage of cystic fibrosis patients Homo sapiens
-
lung the enzyme is commonly found in the lungs of cystic fibrosis patients Homo sapiens
-
additional information the enzyme is commonly found in the bronchioalveolar lavage fluid of lungs of human cystic fibrosis patients, not of healthy human lungs Pseudomonas aeruginosa
-
neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
human SP-D protein + H2O
-
 Pseudomonas aeruginosa SP-D protein peptide fragments cleavage product identification by N-terminal sequencing, overview ?
human SP-D protein + H2O cleavage in the lungs of the cystic fibrosis human host, but not in helathy human hosts Pseudomonas aeruginosa SP-D protein peptide fragments cleavage product identification by N-terminal sequencing, overview ?
N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
-
 Homo sapiens N-methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline
-
 ?
N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
-
 Pseudomonas aeruginosa N-methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline
-
 ?
SP-D protein + H2O
-
 Homo sapiens SP-D protein peptide fragments cleavage product identification by N-terminal sequencing, overview ?
SP-D protein + H2O no activity in healthy lungs, but in 50% of cystic fibrosis patient lungs Homo sapiens SP-D protein peptide fragments cleavage product identification by N-terminal sequencing, overview ?

Synonyms

Synonyms Comment Organism
elastase
-
 Pseudomonas aeruginosa
neutrophil elastase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens
37
-
 assay at Pseudomonas aeruginosa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens
7.5
-
 assay at Pseudomonas aeruginosa