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Literature summary for 3.4.21.37 extracted from

  • Ikegame, Y.; Yamashita, K.; Hayashi, S.I.; Yoshimura, S.I.; Nakashima, S.; Iwama, T.
    Neutrophil elastase inhibitor prevents ischemic brain damage via reduction of vasogenic edema (2010), Hypertens. Res., 33, 703-707.
    View publication on PubMed
Search for more literature for 3.4.21.37

Inhibitors

Inhibitors Comment Organism Structure
sivelestat inhibits the enzyme and reduces brain edema and vascular permeability , and subsequently improves the neurological deficits in an acute focal ischemia. The inhibitor rescues the cultured endothelial cells from neutrophil elastase-induced damage. It can protect the blood-brain barrier function in acute cerebral ischemia Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secereted Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
neutrophil elastase
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction release of neutrophil elastase is one of the harmful inflammatory reactions in acute cerebral ischemia Homo sapiens