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BRENDA support

Literature summary for 3.4.21.37 extracted from

  • Kawahara, Y.; Ninomiya, I.; Fujimura, T.; Funaki, H.; Nakagawara, H.; Takamura, H.; Oyama, K.; Tajima, H.; Fushida, S.; Inaba, H.; Kayahara, M.
    Prospective randomized controlled study on the effects of perioperative administration of a neutrophil elastase inhibitor to patients undergoing video-assisted thoracoscopic surgery for thoracic esophageal cancer (2010), Dis. Esophagus, 23, 329-339.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
sivelestat sodium hydrate a selective inhibitor of neutrophil elastase, the compound is effective in reducing acute lung injury associated with systemic inflammatory response syndrome, SIRS. In patients with thoracic esophageal cancer undergoing thoracoscopic esophagectomy with extended lymph node dissection, the inhibitor treatment prevents postoperative hypercytokinemia and hypoxia secondary to SIRS in a clinical study, overview Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
Homo sapiens
-
neutrophil
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
neutrophil elastase
-
Homo sapiens

General Information

General Information Comment Organism
malfunction inhibition of neutrophil elastase is effective in reducing acute lung injury associated with systemic inflammatory response syndrome, SIRS Homo sapiens