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Literature summary for 3.4.21.37 extracted from

  • Fischer, B.M.; Domowicz, D.A.; Zheng, S.; Carter, J.L.; McElvaney, N.G.; Taggart, C.; Lehmann, J.R.; Voynow, J.A.; Ghio, A.J.
    Neutrophil elastase increases airway epithelial nonheme iron levels (2009), Clin. Transl. Sci., 2, 333-339.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
bronchoalveolar lavage
-
Homo sapiens
-
epithelial cell
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Homo sapiens
-
lung
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
neutrophil elastase
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Homo sapiens

General Information

General Information Comment Organism
malfunction increased neutrophil elastase activity and oxidative stress in the lung can lead to alpha-1-antitrypsin deficiency, A1AT deficiency. Neutrophil elastase digests ferritin increasing the extracellular iron pool available for cellular uptake, it generates reactive oxygen species by increasing lung nonheme iron. Phenotypes of A1AT deficiency patinets and of rats with lungs injured with human neutrophil elastase, overview. The rats show iron-laden macrophages at day 28, but no sideromacrophages Homo sapiens