Literature summary for 3.4.21.37 extracted from

Kolaczkowska, E.; Grzybek, W.; van Rooijen, N.; Piccard, H.; Plytycz, B.; Arnold, B.; Opdenakker, G.
Neutrophil elastase activity compensates for a genetic lack of matrix metalloproteinase-9 (MMP-9) in leukocyte infiltration in a model of experimental peritonitis (2009), J. Leukoc. Biol., 85, 374-381.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	neutrophil elastase expression is associated with the activity of resident peritoneal mast cells and macrophages, neutrophil elastase mRNA and protein expression and activity are enhanced significantly in matrix metalloproteinase-9-deficient mice during late stages of zymosan peritonitis	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
ONO-5046	selective NE inhibitor, also known as elastase inhibitor IV	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
leukocyte	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O	-	Mus musculus	N-methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline	-	?

Synonyms

Synonyms	Comment	Organism
neutrophil elastase	-	Mus musculus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0002	-	ONO-5046	-	Mus musculus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000044	-	-	Mus musculus	ONO-5046

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Release 2023.1 (January 2023)