Literature summary for 3.4.21.37 extracted from

Mydel, P.; Shipley, J.M.; Adair-Kirk, T.L.; Kelley, D.G.; Broekelmann, T.J.; Mecham, R.P.; Senior, R.M.
Neutrophil elastase cleaves laminin-332 (laminin-5) generating peptides that are chemotactic for neutrophils (2008), J. Biol. Chem., 283, 9513-9522.

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Inhibitors

Inhibitors	Comment	Organism	Structure
N-methoxysuccinyl-Ala-Ala-Pro-Val-chloromethyl ketone	neutrophil elastase-specific inhibitor	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
laminin-332 + H2O	neutrophil elastase shows the greatest activity toward the gamma2 chain of laminin-332, in addition, neutrophil elastase cleaves a synthetic peptide derived from the region of human laminin gamma2 containing the matrix metalloproteinase-2 cleavage site, suggesting that neutrophil elastase may generate laminin-332 fragments that are also promigratory	Mus musculus	?	-	?
N-methoxy-succinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O	-	Mus musculus	N-methoxy-succinyl-Ala-Ala-Pro-Val + 4-nitroaniline	-	?
N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O	-	Mus musculus	N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline	-	?

Synonyms

Synonyms	Comment	Organism
neutrophil elastase	-	Mus musculus

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Release 2023.1 (January 2023)