Literature summary for 3.4.21.37 extracted from

Guyot, N.; Butler, M.W.; McNally, P.; Weldon, S.; Greene, C.M.; Levine, R.L.; ONeill, S.J.; Taggart, C.C.; McElvaney, N.G.
Elafin, an elastase-specific inhibitor, is cleaved by its cognate enzyme neutrophil elastase in sputum from individuals with cystic fibrosis (2008), J. Biol. Chem., 283, 32377-32385.

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Inhibitors

Inhibitors	Comment	Organism	Structure
alpha-1-antichymotrypsin	-	Homo sapiens
alpha-1-antitrypsin	neutrophil elastase is inactivated by 0.005 mg of alpha-1-antitrypsin for 30 min	Homo sapiens
elafin	substrate inhibitor of neutrophil elastase, the purified fragments of the cleaved inhibitor elafin, Lys6-Gln57 and Ser10-Gln57, are also still active for inhibiting neutrophil elastase	Homo sapiens
additional information	neither leupeptin, E-64, pepstatin A, benzamidine, soybean trypsin inhibitor, Nalpha-tosyl-L-lysine chloromethyl ketone, N-p-tosyl-L-phenylalanine chloromethyl ketone, EDTA, GM6001, nor phosphoramidon have any inhibitory effect	Homo sapiens
N-(methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone	-	Homo sapiens
pefabloc	-	Homo sapiens
secretory leukoprotease inhibitor	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
elafin + H2O	Homo sapiens	elafin is cleaved by its cognate enzyme neutrophil elastase, neutrophil elastase-mediated cleavage of elafin abolishes the capacity of the inhibitor to cross-link to fibronectin by transglutamination, neutrophil elastase-mediated cleavages of elafin at Val5-Lys-6 and Val9-Ser10 peptide bonds only occur with 2x excess of neutrophil elastase, a partial cleavage of the inhibitor is identified at the scissile peptide bond Ala24-Met25	?	-	?
Fibronectin + H2O	Homo sapiens	-	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
sputum	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
elafin + H2O	elafin is cleaved by its cognate enzyme neutrophil elastase, neutrophil elastase-mediated cleavage of elafin abolishes the capacity of the inhibitor to cross-link to fibronectin by transglutamination, neutrophil elastase-mediated cleavages of elafin at Val5-Lys-6 and Val9-Ser10 peptide bonds only occur with 2x excess of neutrophil elastase, a partial cleavage of the inhibitor is identified at the scissile peptide bond Ala24-Met25	Homo sapiens	?	-	?
Fibronectin + H2O	-	Homo sapiens	?	-	?
N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O	-	Homo sapiens	N-methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline	-	?

Synonyms

Synonyms	Comment	Organism
neutrophil elastase	-	Homo sapiens

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Release 2023.1 (January 2023)