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Literature summary for 3.4.21.37 extracted from

  • Henriksen, P.A.; Sallenave, J.M.
    Human neutrophil elastase: mediator and therapeutic target in atherosclerosis (2008), Int. J. Biochem. Cell Biol., 40, 1095-1100.
    View publication on PubMed

Application

Application Comment Organism
medicine neutrophil elastase is a mediator of atherosclerotic plaque development and a therapeutic target in atherosclerosis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
alpha-1-antitrypsin
-
Homo sapiens
elafin
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens human neutrophil elastase induces interleukin-8 release from HUVEC cells ?
-
?
plasminogen + H2O Homo sapiens
-
miniplasminogen + ?
-
?
plasminogen activator inhibitor type-1 + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
atherosclerotic plaque
-
Homo sapiens
-
HUVEC cell
-
Homo sapiens
-
umbilical vein endothelial cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information human neutrophil elastase induces interleukin-8 release from HUVEC cells Homo sapiens ?
-
?
plasminogen + H2O
-
Homo sapiens miniplasminogen + ?
-
?
plasminogen activator inhibitor type-1 + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
neutrophil elastase
-
Homo sapiens