Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | potent ability of leukotriene B4 to induce cell-surface expression of neutrophil elastase | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | enzyme-deficient mice do not show inhibition of leukocyte transmigration through leukotriene B4-stimulated cremasteric venules after application of inhibitor ONO-5046, enzyme-deficient mice appear to exhibit compensatory mechanisms in regulation of leukocyte transmigration | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ONO-5046 | a specific inhibitor | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | of neutrophils | Mus musculus | 9986 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | involvement of neutrophil elastase in leukotriene B4-induced neutrophil transmigration in vivo, specific NE inhibitor suppresses neutrophil migration through IL-1beta-stimulated cremasteric venules at the level of the basement membrane | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
male C57BL/6 mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone marrow | - |
Mus musculus | - |
commercial preparation | - |
Mus musculus | - |
neutrophil | from bone marrow | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | involvement of neutrophil elastase in leukotriene B4-induced neutrophil transmigration in vivo, specific NE inhibitor suppresses neutrophil migration through IL-1beta-stimulated cremasteric venules at the level of the basement membrane | Mus musculus | ? | - |
? | |
N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O | a fluorogenic enzyme-specific substrate | Mus musculus | N-methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline | - |
? |
Synonyms | Comment | Organism |
---|---|---|
neutrophil elastase | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | - |
assay at | Mus musculus |