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Literature summary for 3.4.21.37 extracted from

  • Lombard, C.; Arzel, L.; Bouchu, D.; Wallach, J.; Saulnier, J.
    Human leukocyte elastase hydrolysis of peptides derived from human elastin exon 24 (2006), Biochimie, 88, 1915-1921.
    View publication on PubMed
Search for more literature for 3.4.21.37

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetics Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Elastin + H2O Homo sapiens generation of soluble peptides by limited proteolysis, elastin-derived peptides play roles in cell migration, differentiation, proliferation, chemotaxis, tumor progression, and up-regulation of metalloproteinases, the sequence GXXPG is required within the enzyme to stimulate the cellular effects, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
polymorphonuclear leukocyte
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
875
-
 substrate N-succinyl-Ala-Ala-Ala-4-nitroanilide Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(VGVAPG)2V + H2O human elastin exon 24-derived peptide substrate, hydrolysis by the enzyme occurs when its active site is fully occupied by the substrate, cleavage at Val-Ala and at Gly-Val bonds, the latter to a lesser extent Homo sapiens VGVAPGVGV + APGV + VGVAPG + VGVAPGV
-
 ?
(VGVAPG)3V + H2O human elastin exon 24-derived peptide substrate, hydrolysis by the enzyme occurs when its active site is fully occupied by the substrate, cleavage at Val-Ala and at Gly-Val bonds, the latter to a lesser extent Homo sapiens VGVAPGVGV + APGVGVAPGV + VGVAPGVGVAPGVGV + APGV + VGVAPG + VGVAPGVGVAPGV + GVAPGV
-
 ?
APG(VGVAPG)2 + H2O human elastin exon 24-derived peptide substrate, hydrolysis by the enzyme occurs when its active site is fully occupied by the substrate, cleavage at Val-Ala and at Gly-Val bonds, the latter to a lesser extent Homo sapiens APGVGV + APGVAPGV + APGVGVAPGVGV + APGVGVAPG + APGV + VGVAPGV
-
 ?
Elastin + H2O generation of soluble peptides by limited proteolysis, elastin-derived peptides play roles in cell migration, differentiation, proliferation, chemotaxis, tumor progression, and up-regulation of metalloproteinases, the sequence GXXPG is required within the enzyme to stimulate the cellular effects, overview Homo sapiens ?
-
 ?
Elastin + H2O human substrate, generation of soluble peptides by limited proteolysis Homo sapiens ?
-
 ?
additional information product determination by mass spectrometry, overview, no activity with elastin exon 24-derived peptide VGVAPGV Homo sapiens ?
-
 ?
N-succinyl-Ala-Ala-Ala-4-nitroanilide + H2O
-
 Homo sapiens N-succinyl-Ala-Ala-Ala + 4-nitroaniline
-
 ?
VAPGVGVAPGV + H2O human elastin exon 24-derived peptide substrate, hydrolysis by the enzyme occurs when its active site is fully occupied by the substrate, cleavage at Val-Ala and at Gly-Val bonds, the latter to a lesser extent Homo sapiens VAPGVGV + APGV + VAPGV + GVAPGV
-
 ?

Synonyms

Synonyms Comment Organism
leukocyte elastase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
 assay at room temperature Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.6
-
 assay at Homo sapiens