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Literature summary for 3.4.21.37 extracted from

  • Potempa, J.; Dubin, A.; Watorek, W.; Travis, J.
    An elastase inhibitor from equine leukocyte cytosol belongs to the serpin superfamily. Further characterization and amino acid sequence of the reactive center (1988), J. Biol. Chem., 263, 7364-7369.
    View publication on PubMed
Search for more literature for 3.4.21.37

Inhibitors

Inhibitors Comment Organism Structure
horse leukocyte elastase inhibitor protein with a molecular weight of 35200 Da that forms sodium dodecylsulfate-stable equimolar complexes with elastase Equus caballus
horse leukocyte elastase inhibitor protein with a molecular weight of 35200 Da that forms sodium dodecylsulfate-stable equimolar complexes with elastase Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Elastin + H2O Homo sapiens involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged ? protein cleaved at at least one location ?
Elastin + H2O Equus caballus involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged ? protein cleaved at at least one location ?

Organism

Organism UniProt Comment Textmining
Equus caballus
-
-
-
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leukocyte
-
 Homo sapiens
-
leukocyte
-
 Equus caballus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Elastin + H2O
-
 Homo sapiens ?
-
 ?
Elastin + H2O
-
 Equus caballus ?
-
 ?
Elastin + H2O involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged Homo sapiens ? protein cleaved at at least one location ?
Elastin + H2O involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged Equus caballus ? protein cleaved at at least one location ?
methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
-
 Homo sapiens methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline
-
 ?
methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
-
 Equus caballus methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline
-
 ?